ABSTRACT
Objective To research the effect of Qishenghuoxue granules in the treatment of sepsis combined with myocardial injury.Methods A total of 63 patients with sepsis combined with myocardial injury were randomly divided into two groups:33 cases in control group (conventional therapy for 7 d) and 30 cases in observation group (Qishenhuoxue granule for 7 d).Thromboxane A2 (TXA2),prostaglandin I2 (PGI2),endothelin 1 (ET-1) and other cytokines were detected by enzyme-linked immunosorbent assay (ELISA).At the same time blood pressure,pulse,echocardiography were recorded.The mortality rate at the 28th day and the above values were statistically analyzed.Results On the 7th day after the intervention of Qishenhuoxue granule,N-terminal pro-brain natriuretic peptid (NT-proBNP) and troponin T (TNT) in the observation group and the control group were significantly lower than those on the 1 st day,but there was no significant difference between the two groups at the same time point (P ＞0.05);On the 7th day after the intervention of Qishenhuoxue granule,the levels of angiotensin Ⅱ (Ang-Ⅱ) and ET-1 in the observation group were significantly lower than those in the control group (P ＜ 0.01),but there was no significant difference between the two groups in cardiac function index and 28 day mortality.Conclusions The Chinese herbal preparation Qishenhuoxue granule could reduce the blood levels of Ang-Ⅱ and ET-1,but its effect on improving myocardial injury is still worthy of further study.
ABSTRACT
Objective@#To research the effect of Qishenghuoxue granules in the treatment of sepsis combined with myocardial injury.@*Methods@#A total of 63 patients with sepsis combined with myocardial injury were randomly divided into two groups: 33 cases in control group (conventional therapy for 7 d) and 30 cases in observation group (Qishenhuoxue granule for 7 d). Thromboxane A2 (TXA2), prostaglandin I2 (PGI2), endothelin 1 (ET-1) and other cytokines were detected by enzyme-linked immunosorbent assay (ELISA). At the same time blood pressure, pulse, echocardiography were recorded. The mortality rate at the 28th day and the above values were statistically analyzed.@*Results@#On the 7th day after the intervention of Qishenhuoxue granule, N-terminal pro-brain natriuretic peptid (NT-proBNP) and troponin T (TNT) in the observation group and the control group were significantly lower than those on the 1st day, but there was no significant difference between the two groups at the same time point (P>0.05); On the 7th day after the intervention of Qishenhuoxue granule, the levels of angiotensin Ⅱ (Ang-Ⅱ) and ET-1 in the observation group were significantly lower than those in the control group (P<0.01), but there was no significant difference between the two groups in cardiac function index and 28 day mortality.@*Conclusions@#The Chinese herbal preparation Qishenhuoxue granule could reduce the blood levels of Ang-Ⅱ and ET-1, but its effect on improving myocardial injury is still worthy of further study.
ABSTRACT
Objective To study the effect of Qishenhuoxue granule on serum inflammatory response in children with pneumonia complicated with sepsis. Methods A total of 138 children with pneumonia complicated with sepsis who were admitted to our hospital from July 2014 to June 2016 were enrolled in this study. Children were randomly divided into observation group and control group. The patients in both groups were treated with conventional Western medicine symptomatic support. The observation group was treated with Qishenhuoxue granule. The curative effect was determined after treatment. Interleukin-6 (IL-6), interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α), serum procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP), CD4+CD25+regulatory T cell (Treg cells) ratio value, creatine kinase-MB (CK-MB), creatinine (Scr), aspartic transaminase (AST) and brain natriuretic peptide (BNP) were measured before and 7 days after the treatment. Data of mortality and duration of pediatric intensive care unit (PICU) stay during treatment and adverse events were recorded during treatment. Results The total effective rate was 89.86% in the observation group, which was significantly higher than that of control group (71.01%, P<0.01). The levels of IL-6, IL-10, TNF-α, PCT, hs-CRP and Treg cell ratio were significantly lower after 7-day treatment in two groups than those before treatment (P<0.05), and levels of IL-6, IL-10, TNF-α, PCT, hs-CRP and Treg cell ratio were significantly lower in observation group than those in control group ( P<0.05). The CK-MB, Scr, AST and BNP were reduced after 7-day treatment in two groups, and those data were significantly lower in observation group than those of the control group (P<0.05). The 28-day mortality and the number of PICU days were significantly lower in observation group than those in control group (P<0.05). No adverse reactions were found in the both groups. Conclusion Qishenhuoxue granule can decrease the inflammatory response in children with pneumonia complicated with sepsis and improve the therapeutic effect. It is safe and effective and worthy of clinical recommendation.